This is a young African American female with angioedema after being started on an ACE inhibitor for essential hypertension.
- In angioedema, extreme swelling occurs in the presence of inflammatory mediators that induce transudation of fluid into the dermis and subcutaneous tissue. - The pathophysiology of angioedema can be IgE mediated, complement mediated, related to physical stimuli, autoantibody mediated, or idiopathic. - Angiotensin-converting enzyme inhibitors (ACEIs) are known to cause angioedema through inhibition of breakdown of bradykinin, which acts as an inflammatory vasodilator. - ACE inhibitors should be stopped as soon as possible when suspected to be the cause of angioedema. Even an angiotensin receptor blocker (ARB) can cause angioedema and should be suspected in a patient on this class of medication.
Angioedema, often associated with ACE-Inhibitors.
ReplyDeleteThis is a young African American female with angioedema after being started on an ACE inhibitor for essential hypertension.
ReplyDelete- In angioedema, extreme swelling occurs in the presence of inflammatory mediators that induce transudation of fluid into the dermis and subcutaneous tissue.
- The pathophysiology of angioedema can be IgE mediated, complement mediated, related to physical stimuli, autoantibody mediated, or idiopathic.
- Angiotensin-converting enzyme inhibitors (ACEIs) are known to cause angioedema through inhibition of breakdown of bradykinin, which acts as an inflammatory vasodilator.
- ACE inhibitors should be stopped as soon as possible when suspected to be the cause of angioedema. Even an angiotensin receptor blocker (ARB) can cause angioedema and should be suspected in a patient on this class of medication.