The skin condition shown here is acanthosis nigricans. This condition manifests with hyperpigmented, velvety-appearing plaques. Most commonly, it is found on flexor surfaces or in intertriginous areas (areas of the body where two surfaces of skin meet, i.e. axilla or back of the neck). It is commonly associated with insulin resistance and diabetes type 2, but can also be found in patients with obesity and polycystic ovarian syndrome (PCOS). Abrupt onset of acanthosis nigricans is concerning for a gastrointestinal malignancy. The pathophysiology of this condition is not fully understood, but thought to be associated with stimulation of growth factor receptors on keratinocytes. Treating the underlying condition usually results in regression of the lesions.
The skin condition shown here is acanthosis nigricans. This condition manifests with hyperpigmented, velvety-appearing plaques. Most commonly, it is found on flexor surfaces or in intertriginous areas (areas of the body where two surfaces of skin meet, i.e. axilla or back of the neck). It is commonly associated with insulin resistance and diabetes type 2, but can also be found in patients with obesity and polycystic ovarian syndrome (PCOS). Abrupt onset of acanthosis nigricans is concerning for a gastrointestinal malignancy. The pathophysiology of this condition is not fully understood, but thought to be associated with stimulation of growth factor receptors on keratinocytes. Treating the underlying condition usually results in regression of the lesions.
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